Blackberries decrease DNA damage after 3 h, but not after 6 d, in healthy adult volunteers

Decrease in 3*/ 6* Nicotinic Receptors but Not Nicotine- Evoked Dopamine Release in Monkey Brain after Nigrostriatal Damage

Nicotinic acetylcholine receptors (nAChRs) are decreased in the striata of patients with Parkinson’s disease (PD) or in experimental models after nigrostriatal damage. Because presynaptic nAChRs on striatal dopamine terminals mediate dopamine release, receptor loss may contribute to behavioral deficits in PD. The present experiments were done to determine whether nAChR function is affected by n...

Evaluating Gamma-H2AX Expression as a Biomarker of DNA Damage after X-ray in Angiography Patients

Objective: Coronary heart disease (CHD) is one of the most common diseases. Coronary angiography (CAG) is an important apparatus used to diagnose and treat this disease. Since angiography is performed through exposure to ionizing radiation, it can cause harmful effects induced by double-stranded breaks in DNA which is potentially life-threatening damage. The aim of the present study is to inves...

Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers.

EDP-420 (EP-013420, S-013420) is a first-in-class bicyclolide (bridged bicyclic macrolide) currently in clinical development for the treatment of respiratory tract infections. It has good preclinical pharmacokinetic properties across multiple species and potent in vitro and in vivo activity against respiratory tract infection pathogens, including Haemophilus influenzae, atypical organisms (e.g....

Arterial blood gases after atropine sulphate in healthy volunteers.

Hyperoxia does not affect oxygen delivery in healthy volunteers while causing a decrease in sublingual perfusion

OBJECTIVE To determine the human dose-response relationship between a stepwise increase in arterial oxygen tension and its associated changes in DO2 and sublingual microcirculatory perfusion. METHODS Fifteen healthy volunteers breathed increasing oxygen fractions for 10 minutes to reach arterial oxygen tensions of baseline (breathing air), 20, 40, 60 kPa, and max kPa (breathing oxygen). Syste...